Development of copper-dependent antimicrobial resistance breakers

Antibiotics are life savers in the field of bacterial infectious diseases. However, several bacterial species are developing resistance against antibiotics, rendering an increasing threat to today’s clinical settings and public health. Beta-lactam antibiotics are one of the most prescribed drugs for treating a variety of bacterial infections. Bacteria produces beta-lactamase enzymes in order to inhibit beta-lactam antibiotics. NDM-1, a metallo-beta-lactamase enzyme, has been found in New Delhi, India in 2008 and since then, several antibiotics have been reportedly failed due to this bacterial enzyme. Therefore, developing a resistance breaker is at an urgent need to stop this enzyme production and inhibitory action of bacteria. 

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